US stocks have slipped in opening trade despite promising growth data from China and troubled Spain's holding a bond auction at lower borrowing rates.
A high number for weekly unemployment claims erased hopes from the previous week's sharp fall that the job market was rebounding.
Five minutes into trade on Thursday, the broad-based S&P 500 was down 3.20 points, or 0.22 per cent, at 1,457.71.
The tech-rich Nasdaq lost 9.24 points, or 0.30 per cent, to 3,094.88.
The narrower Dow Jones Industrial Average of 30 blue chips lost 15.67 points, or 0.12 per cent, to 13,541.33.
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