GlaxoSmithKline full-year profit slides

BRITISH drugmaker GlaxoSmithKline (GSK) has announced a 13 per cent drop in annual profits and said it would further restructure its European operations to deliver greater savings amid weaker sales across the region.

GSK said profit after tax fell to STG4.565 billion ($A6.92 billion) in 2012 from STG5.261 billion a year earlier.

Group sales dropped 3.5 per cent to 26.431 billion, GSK added in an earnings statement.

Chief executive Andrew Witty said the company was extending its European restructuring program "to deliver annual cost savings of at least one billion by 2016."

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